Charles River & The Jackson Laboratory Seminar Series – Copenhagen

As the exclusive distributor and breeder of JAX^® Mice in Europe, Charles River is pleased to welcome Dr. Katie Zyuzin from The Jackson Laboratory to our European seminar series. Secure your spot today to attend relevant talks by international experts on laboratory animal science and advanced research models and to discuss and network with your peers and experts. Registration is free, but mandatory, and seats are limited.

Agenda

13h15 – 13h30     Registration & Welcome

13h30 – 15h00     Fundamentals of Mouse Colony Management Workshop*  

This workshop offers a compact educational experience, providing both novel and experienced mouse users with the opportunity to learn about the following:

• Deciphering and properly using mouse nomenclature
• The detrimental impacts of genetic drift in mouse colonies on experimental reproducibility
• Efficiently managing mouse colonies in alignment with the principles of the 3Rs: Replacement, Reduction, and Refinement, with additional considerations for reducing sex bias in research

Presenter: Katie Zyuzin, PhD, The Jackson Laboratory

*For the best experience, bring your laptop or internet-ready device to access our freely available resources in real-time.

15h00 – 15h30     Coffee Break

15h30 – 16h00     Diet Considerations for Cancer Research in Rodent Models

Studies involving cancer in animal models have progressed significantly and there are several mouse models in current use.  As cancer risk is increased with obesity and metabolic comorbidities, certain diet-driven models have been employed to understand the underpinnings of the mechanisms involved in tumor development.  Cancer models in combination with certain metabolic disease / obesity-inducing diets can drive further development of cancers.

High fat diets with 30 – 60 kcal% fat are commonly used for diet-induced obesity in mouse models and are frequently used in cancer studies involving various cancer models.  In addition, there is a potential influence by gut microbiota to affect cancer development, thus diet choice and dietary controls should be properly considered when studying a diet-driven effect on tumor formation. We will outline:

• Differences between purified and grain-based diets
• Diets commonly used for driving obesity and examples where diets have driven tumor growth in cancer models
• The influence of diet, including fiber, on gut microbiome, and implications in cancer models
• Other considerations such as gender and dietary components such as phytoestrogens

Presenter: Michael A. Pellizzon, PhD, Research Diets Inc.

16h00 – 16h30     Comparing Immune-humanized Mouse Platforms for Pre-clinical Applications

Precise modeling of human immune responses for disease and therapeutic evaluation is possible in the highly immunodeficient NSG^® platform. During this presentation, we will discuss strategies for immune-humanization to support translatable and predictive preclinical immunology and oncology research. Join us to learn about:

• Various immune cell humanization techniques
• How host selection and genetic modifiers such as growth factors, HLA transgenic variants, and others beneficially impact resulting engrafted immunophenotypes
• Examples of current preclinical research using humanized mouse models

Presenter: Katie Zyuzin, PhD, The Jackson Laboratory

16h30 – 17h00     Pre-clinical Models of Cancer

Presenter: Anne Skovsbo Clausen, DVM, PhD, University of Copenhagen